Personale docente

Marta De Zotti

Ricercatore a tempo determinato di tipo B

CHIM/06

Indirizzo: VIA F. MARZOLO, 1 - PADOVA . . .

Telefono: 0498275280

E-mail: marta.dezotti@unipd.it

2000: 7 months at NTNU (Norway) with ERASMUS and NTNU fellowships: enzyme catalyzed organic reactions.
2002: Master degree (Laurea) in Chemistry.
2006: Stage at Giessen University (Germany): advanced peptides' characterization.
2007: Stage at Chosun University (South Korea): peptides' proteolysis and bioactivity.
2007: Ph.D. in Chemistry.
2007-2011: post-doc: membrane active peptaibols, synthesis and study.
2011-2013: Senior post-doc activity – University of Padova.
2012: Post-doc at Manchester University (UK, Prof. J.Clayden): advanced organic syntheses.
2014-2018: RTD-A researcher. Principal Investigator of a Future in Research Natonal Project.
2018-present: RTD-B Researcher

2003-present: Participant in national funding projects.

Research Activity:
Organic Chemistry. Synthesis of peptides containing non-coded amino acids. Spectroscopical studies. Conformational analysis (CD, FT-IR, 2D-NMR, MD calculations, X-ray diffraction).

Research Interests:
ANTIMICROBIAL/ANTITUMOR PEPTIDES
PEPTIDE-BASED MOLECULAR DEVICES: TOWARDS NEW SMART MATERIALS.

Scientific contributions:
Co-author of more than 65 publications on ISI journals (six as corresponding author) and of more than 50 European/American Peptide Symposium Proceedings. 10 oral (4 invited) and about 50 poster communications presented at national and international meetings. Reviewer for ISI journals. H-index: 16.

Download Curriculum_De Zotti.pdf

Argomento 1: Chimica biorganica

Il progetto di Tesi prevede la sintesi e lo studio conformazionale di peptidi naturali e loro analoghi ad attività antibatterica e/o antitumorale.
I peptidi in esame, ricchi in amminoacidi naturali non proteinogenici, sono naturalmente resistenti alla degradazione enzimatica e adottano strutture elicoidali stabili.

Argomento 2: Chimica organica applicata ai materiali

Il progetto prevede lo sviluppo di sistemi a base peptidica in grado di modificare la loro conformazione in risposta a stimoli esterni come il cambio di pH o di solvente. I sistemi prodotti verranno ancorati a vari tipi di superfici in modo da studiarne le proprietà elastiche ed elettroniche. Applicazioni di queste MOLLE MOLECOLARI vanno dalla sensoristica ai biomateriali.