* Per gli studenti di CTF - Chimica Organica II (A.A. 2016/17)

 

esempi di esame

 

esame 1 -click-

esame 2 -click-

 

teoria

 

1_presentazione (inserted 07/10/2016) -click-

2_Ch15 (inserted 07/10/2016) -click

3_Ch11 (inserted 13/10/2016) -click

4_Ch17 (inserted 20/10/2016) -click

5_Ch25 (inserted 03/11/2016) -click-

6_Ch18+19 (inserted 11/11/2016) -click- 

7_Ch20 (inserted 22/11/2016) -click- 

8_Ch21 (inserted 30/11/2016) -click- 

9_acidità_intermezzo (inserted 01/12/2016) -click-

10_Ch22 (inserted 02/12/2016) -click- 

11_Ch23 (inserted 16/12/2016) -click- 

12_Ch24 (inserted 10/01/2017) -click-

13_nucleophilicity (inserted 10/01/2017) -click-

 

esercizi

 

1_CTF_201617_exercises01_for11102016 (inserted 07/10/2016) -click

2_CTF_201617_exercises02_for19102016 (inserted 13/10/2016) -click-

3_CTF_201617_exercises03_for08112016 (inserted 03/11/2016) -click-

4_CTF_201617_exercises04 (inserted 11/11/2016) -click-

5_CTF_201617_exercises05 (inserted 22/11/2016) -click-

6_CTF_201617_exercises06 (inserted 23/11/2016) -click-

7_CTF_201617_exercises07 (inserted 02/12/2016) -click-

8_CTF_201617_exercises08 (inserted 16/12/2016) -click-

9_CTF_201617_exercises09 (inserted 12/01/2016) -click-

10_CTF_201617_exercises10 (inserted 12/01/2016) -click-

11_CTF_201617_exercises11 (inserted 12/01/2016) -click-

 

* Per gli studenti di Chimica - Chimica Supramolecolare (A.A. 2015/16)

 

01_History of Supramolecular Chemistry -click-

02_Binding Constants -click-

03_Cooperativity -click-

04_Self-assembly -click-

 

* Per gli studenti di Chimica - Chimica Organica III - Modulo B (A.A. 2015/16)

 

Zip-file con le introduzioni agli sperimenti -click-

Quiz con domande -click- (rispondere alle domande nel quaderno dopo la chiusura del sperimento 6)

 

!! consegna quaderno max 13 maggio 2016 ufficio Prins !!

 

* Per gli studenti di CTF - Chimica Organica II (A.A. 2015/16)

 

 

teoria

 

01_presentazione -click-

02_Ch18+19 -click-

   02_Ch18+19 updated 05/10/2015 -click-

03_Ch20 -click-

04_Ch21 (inserted 09/10/2015) -click-

05_Ch22 (inserted 16/10/2015)  -click

06_Ch23 prima parte (inserted 27/10/2015)  -click

07_Ch23 completa (inserted 30/10/2015) - -click

08_Ch24 (inserted 06/11/2015) - -click

09_Ch17 (inserted 10/11/2015) - -click

09_Ch17_completa (inserted 12/11/2015) - -click

10_Ch25 (inserted 18/11/2015) - -click

11_Ch28 (inserted 27/11/2015) - -click

11_Ch28_updated (inserted 01/12/2015) - -click

12_Ch11 (inserted 01/12/2015) - -click

12_Ch11_updated (inserted 10/12/2015) - -click

13_Ch15 (inserted 10/12/2015) - -click

14_peptide synthesis (inserted 17/12/2015) - -click

15_ripasso (inserted 11/01/2016) -click-

 

esercizi

2015_09_29 esame Chimica Organica I here

esercizi per martedì 6/10/2015 here (inserito 2/10/2015)

esercizi per martedì 20/10/2015 here (inserito 15/10/2015)

esercizi per martedì 27/10/2015 here (inserito 23/10/2015)

esercizi per martedì 03/11/2015 here (inserito 30/10/2015)

esercizi per martedì 10/11/2015 here (inserito 06/11/2015)

esercizi per martedì 17/11/2015 here (inserito 13/11/2015)

esercizi per martedì 24/11/2015 here (inserito 21/11/2015)

esercizi per martedì 01/12/2015 here (inserito 27/11/2015)

esercizi per martedì 15/12/2015 here (inserito 10/12/2015)

 

 

* Per gli studenti di CTF - Chimica Organica I (A.A. 2014/15) - slides

 

Documento separazione di enantiomeri per CTF here. (2015_03_31)

 

Documento sulla differenza in nucleophilicità fra tioli ed alcoli here (2015_04_16)

 

Esempio esame CTF here (2015_04_16)

 

Second example CTF here (2015_05_04)

  

 

* Per gli studenti di SFA - Chimica Organica (A.A. 2014/15) - slides

 

Documenti addizionali per SFA here. (2015_03_24)

 

Esempio esame SFA here (2015_04_14)

 

Second example SFA here and corresponding answers here (2015_05_04)

 

Third example SFA here and corresponding answers here (2015_05_04)

 

 

Proposal MSc-Thesis I

 

‘Self-assembly out-of-equilibrium’

 

Argument

Living organisms need energy to stay alive. Translated into terms of chemistry, this implies that life is a kinetically, rather than thermodynamically, stable state. Over the past decades, chemists have mastered the art of assembling small molecules into complex nanostructures using non-covalent interactions. The driving force for self-assembly is thermodynamics: the self-assembled structure is more stable than the separate components (Figure 1a). Such self-assembled structures are now used as functional catalysts, sensors, and materials. However, they differ in a fundamentally different way from natural systems, which are NOT at thermodynamic equilibrium. The challenge is now to develop chemical systems in the laboratory that require energy consumption to maintain their state (Figure 1b). On one hand, such systems may lead to a better understanding of self-assembly in Nature, but may also may lead to innovative catalysts and sensors.

 

 

Research area

Supramolecular chemistry, organic chemistry, systems chemistry

 

Techniques

Organic synthesis (small molecules and peptides) and characterisation (NMR, MS, IR, UV), gold nanoparticle synthesis and characterisation (NMR, TGA, TEM, DLS), fluorescence and UV/Vis-spectroscopy, LC/MS. Kinetic measurements and titrations. Determination of molecular interactions.

 

For more info

Send an email to: leonard.prins@unipd.it or visit the laboratory.

 

Proposal MSc-Thesis II

 

‘Self-selected molecular receptors using chemical evolution’

 

 

Argument

Chemical systems can display Darwinian evolution on the molecular level. The driving force for evolution is a change in the thermodynamic landscape upon the application of an external stimuli (e.g. a change in pH, the addition of a molecular target, light). This leads to a spontaneous increase in the concentration of species that is best adapted to the new situation. For example, we have recently shown that the addition of a Hg2+ metal ion to a mixture of gold nanoparticles (Au NPs) and the four nucleotides (XMP with X = A, T, G, C) results in the selective binding of TMP to the Au NPs. Remarkably, the addition of Ag+ instead of Hg2+ to the same identical mixture resulted in the self-selection of CMP. This information obtained from the molecules themselves was then used to develop sensing systems able to detect Ag+ or Hg2+ at nanomolar concentrations in water. Now we face the challenge to extend this technology for the development of receptor systems for small molecules.

 

 

Research area

Dynamic combinatorial chemistry, organic chemistry, systems chemistry

 

Techniques

Organic synthesis (small molecules and peptides) and characterisation (NMR, MS, IR, UV), gold nanoparticle synthesis and characterisation (NMR, TGA, TEM, DLS), fluorescence and UV/Vis-spectroscopy, LC/MS. Kinetic measurements and titrations. Determination of molecular interactions.

 

For more info

Send an email to: leonard.prins@unipd.it or visit the laboratory.

 

 

Proposal MSc-Thesis III

 

‘Self-assembly of multivalent catalysts’

 

Argument

Catalyst discovery is one of the central themes of chemistry, because of the growing need for highly efficient and selective chemical transformations with low environmental impact. Catalyst discovery is very challenging as it requires the identification of species able to stabilize elusive and transient transition states along the reaction pathway. Nature offers a tremendous source of inspiration, having at hand an enormous variety of enzymes able to catalyse chemical transformations with astonishing selectivity and activity. Producing catalytic systems that rival the efficiency and complexity of nature’s multi-kDa enzymes is perhaps the Holy Grail for organic, inorganic and supramolecular chemists alike. The strategy that we are pursuing is by self-assembling peptide fragments on the surface of gold nanoparticles. The obtained catalysts have unique properties originating from the multivalent and complexity of the system.

Research area

Supramolecular catalysis, organic chemistry, multivalency

 

Techniques

Organic synthesis (small molecules and peptides) and characterisation (NMR, MS, IR, UV), gold nanoparticle synthesis and characterisation (NMR, TGA, TEM, DLS), fluorescence and UV/Vis-spectroscopy, LC/MS. Kinetic measurements and titrations. Determination of molecular interactions.

 

For more info

Send an email to: leonard.prins@unipd.it or visit the laboratory.