UNIVERSITY OF PADOVA - DEPARTMENT OF CHEMICAL SCIENCES

Prof. PAOLO M. SCRIMIN                                                                                                
 Photo by Prof. A. Kirby


CLICCARE QUI PER ACCEDERE ALLE DIAPOSITIVE DELLE LEZIONI
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Bio: Born 1952. Married, two children. Education: Doctor of Chemistry, University of Padova, 1976. Positions: Assistant Professor, University of Ferrara 1979-1983. Assistant Professor, University of Padova, 1983-1985. Associate Professor, University of Padova, 1985-1994. Full Professor, University of Trieste, 1994-1997. Full Professor, University of Padova, 1997 to date. Member of the Board of Directors of the Organic Chemistry Division of the Italian Chemical Society. Honors and awards: 1981: CNR/NRCI Fellow, University of Jerusalem, Israel. 1985-1986; Fulbright Scholar, Rutgers University, NJ, USA. 1992-1993; Senior Fulbright Scholar, University of California, Santa Barbara, USA; Visiting Professor, Université Louis Pasteur, Strasbourg, France 2006. Ciamician Medal (1988). Italian Chemical Society, Organic Chemistry Division, Research award (2003).

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Group associates:          Prof. Giulia Licini 

                                          Dr. Leonard Prins 

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RESEARCH GROUP TOPICS: METAL ION-BASED MOLECULAR SYSTEMS: NEW REGIO- AND STEREOSELECTIVE CATALYSTS, ARTIFICIAL METALLOENZYMES, NANOSTRUCTURES

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Ongoing projects:

1. Synthetic models of metallonucleases (more)

2. Permeability control of synthetic liposomes (more)

3. Allosteric control of activity by metal ions (more)

4. Metal ions-mediated self-assembling of nanostructures

5. Stereoselective oxidation of organic compounds mediated by chiral peroxocomplexes of transition metal ions (see Prof. G. Licini)

6. Synthesis and application in stereoselective catalysis of chiral, highly symmetrical polydentate ligands (see Prof. G. Licini)

7. Functionalized gold nanoparticles as enzyme models 

Recent Publications:

L. Pasquato, P. Pengo, P. Scrimin
Biological and Biomimetic Applications of Nanoparticles in “Nanoparticles. Building Blocks for Nanotecnology” V. Rotello,  Ed.; Kluver Academic/Plenum Publishers: New York, 2004; pp 251-282.

A. Scarso, P. Scrimin
DNA and RNA-cleaving Pseudo-peptides
In “Pseudo-peptides in Drug Discovery”, Nielsen, P. E., Editor, Wiley-VCH, Weinheim, 2004; chapter 4, pp. 223-240.

U. Pichler, P. Scrimin, P. Tecilla, U. Tonellato, A. Veronese, M. Verzini
Efficient and Selective Transport of w-Amino Acids Across a Bulk Chloroform Membrane by a Macrocyclic Dicopper(II) Complex
Tetrahedron Lett. 2004, 45, 1643-1646.

F. Formaggio, A. Barazza, A. Bertocco, C. Toniolo, Q. B. Broxterman, B. Kaptein, E. Brasola, P. Pengo, L. Pasquato, P. Scrimin
Role of Secondary Structure in the Asymmetric Acylation Reaction Catalyzed by Peptides Based on Chiral Ca-Tetrasubstituted a-Amino Acids
J. Org. Chem. 2004, 69, 3849-3856.

P. Rossi, P. Tecilla, L. Baltzer, P. Scrimin
De-novo Metallonucleases Based on Helix-loop-helix Motifs
Chem. Eur. J. 2004, 10, 4163-4170.

M. Lucarini, P. Franchi, G. F. Pedulli, P. Pengo, P. Scrimin,  L. Pasquato
EPR Study of Dialkyl Nitroxides as Probes to Investigate the Exchange of Solutes between the Ligand Shell of Monolayers of Protected Gold Nanoparticles and Aqueous Solutions J. Am. Chem. Soc. 2004, 126, 9326-9329.

F. Manea, F. Bodar Houillon, L. Pasquato, P. Scrimin
Nanozymes: Gold-nanoparticles-based Transphosphorylation Catalysts
Angew. Chem. Int. Ed. 2004, 43, 6165-6169.

L. Pasquato, P. Pengo, P. Scrimin
Functional Gold Nanoparticles for Recognition and Catalysis
J. Mater. Chem. 2004, 14, 3481-3487.

G. Licini, L. J. Prins, P. Scrimin
Oligopeptide Foldamers: from Structure to Function
Eur. J. Org. Chem., 2005, 969-977.

M. G. Buonomenna, E. Drioli, W. A. Nugent, L. J. Prins, P. Scrimin,  G. Licini
Ti(IV)-based catalytic membranes for efficient and selective oxidation of secondary amines
Tetrahedron Lett. 2004, 45, 7515-7518.

L. Pasquato, P. Pengo, P. Scrimin
Nanozymes: Functional Nanoparticles-based Catalysts
Supram. Chem. 2005, 17, 163-171.

L. J. Prins, P. Scrimin
Artificial (Pseudo)peptides for Molecular Recognition and Catalysis in Functional Synthetic receptors, T. Schrader and A. D. Hamilton Eds., Wiley-VCH,
Weinheim, 2005, pp 1-43.

P. Pengo, S. Polizzi, L. Pasquato, P. Scrimin
Carboxylate-Imidazole Cooperativity in Dipeptide-Functionalized Gold Nanoparticles with Esterase-like Activity
J. Am. Chem. Soc. 2005, 127, 1616-1617.

F. Mancin, P. Scrimin, P. Tecilla, U. Tonellato
Artificial Metallonucleases
Chem. Commun. 2005, 2540-2548.

C. Guarise, L. Pasquato, P. Scrimin
Reversible Aggregation/deaggregation of Gold Nanoparticles Induced by a Cleavable Dithiol Linker
Langmuir 2005 , 21, 5537-5541.

M. G. Buonomenna, E. Drioli, G. Licini, P. Scrimin
Catalytic polymeric membranes. New catalytic polymeric membranes incorporating Ti(IV) trialkanolamines complexes: synthesis, characterization and application in catalysis in Microreactor Technology and Process Identification, ACS Symposium Series 914, American Chemical Society, Washington D. C., 2005, pp 309-321.

G. Licini, M. Bonchio, Q. B. Broxterman, B. Kaptein, A. Moretto, C. Toniolo, P. Scrimin
Ca-Tetrasubstituted Amino Acid-Based Peptides in Asymmetric Catalysis
Biopolymers (Peptide Science) 2006, 84, 97-104.

M. Lucarini, P. Franchi, G. F. Pedulli, C. Gentilini, S. Polizzi, P. Pengo, P. Scrimin, L. Pasquato
Effect of Core Size on the Partition of Organic Solutes in the Monolayer of Water-Soluble Nanoparticles: An ESR Investigation
J. Am. Chem. Soc. 2005 , 127, 16384-16385.

C. Guarise, L. Pasquato, V. De Filippis, P. Scrimin
Gold nanoparticles-based protease assay
Proc. Natl. Acad. Sci. USA 2006, 103, 3978-3982.

M.G. Buonomenna, E. Drioli, R. Bertoncello, L. Milanese, L. J. Prins, P. Scrimin, G. Licini
Ti(IV)/trialkanolamine catalytic polymeric membranes: Preparation, characterization, and use in oxygen transfer reactions
J. Catal. 2006, 238, 221-231.

G. Zaupa, M. Martin, L. J. Prins, P. Scrimin
Determination of the Activity of Heterofunctionalyzed Catalysts from Mixtures.
New J. Chem. 2006, 30, 1493 – 1497.

C. Guarise, L. J. Prins, P. Scrimin
Fully Symmetrical Functionalization of Multivalent Scaffold Molecules on Solid Support
Tetrahedron 2006, 62, 11670-11674.

P. Pengo, L. Baltzer, L. Pasquato, P. Scrimin
Substrate Modulation of the Activity of an Artificial Nanoesterase Made of Peptide-functionalized Gold Nanoparticles.
Angew. Chem. Int. Ed. 2007, 46, 400-404.

M. Bellanda,  S. Mammi, S. Geremia, N. Demitri, L. Randaccio, Q. B. Broxterman, B. Kaptein, P. Pengo, L. Pasquato, P. Scrimin
Solvent Polarity Controls the Helical Conformation of Short Peptides Rich in Ca-Tetrasubstituted Amino Acids
Chem. Eur. J. 2007, 13, 407-416.

A. Scarso, G. Zaupa, F. Bodar Houillon, L. J. Prins, P. Scrimin
Tripodal, cooperative, and allosteric transphosphorylation metallocatalysts
J. Org. Chem. 2007, 72, 376-385.

Partly updated 2/07


 
 

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