Dr. Lev M. Weiner - Weizmann Institute of Science

 

Dr. Lev M. Weiner, Scientific Advisor, Weizmann Institute of Science, 76100 Rehovot, Israel.

Phone: 972 8 9343410; Fax: 972 8 9344124; E-mail: lev.weiner@weizmann.ac.il.

PhD. in Physical Chemistry, 1975 (supervisor prof. Yu.N. Molin)

Novosibirsk, Russia.

Affiliation:

1976-1989 Inst. of Chemical Kinetics and Combustion, Novosibirsk, Russia

1990 – Weizmann Institute of Science, Rehovot, Israel

Research activities:

His research interests are in the field of application of the modern methods of Electron Spin Resonance (ESR) spectroscopy, spin labeling and spin trapping techniques, stable nitroxyl radicals, as well as fluorescent spectroscopy in biophysical and medical studies. In cooperation with my colleagues, I pioneered in describing and application of the nitroxyls possessing pH-dependent ESR spectra in biophysical research. Method used now for ESR Imaging in cells and ESR in vivo.

Selected recent publications:

- Grzyb, J., Xu, F., Weiner, L., Reijerse, E.J., Lubitz, W., Nanda. V. and Noy, D: De novo design of a non-natural fold for an iron-sulfur protein: Alpha-helical coiled-coil with a four-iron four-sulfur cluster binding site in its central core. Biochim. Biophys. Acta 1797, 406-413 (2010)

- Ettedgui, J., Diskin-Posner, Y.. Weiner, L. and Neumann, R.: Photoreductionof Carbon Dioxide to Carbon Monoxide with Hydrogen Catalyzed by a Rhenium(I) phenanthrolinePolyoxometalate Hybrid Complex. J. Amer. Chem. Soc. 133, 188-190 (2011)

- Paz, A., Sussman, J. L., Shnyrov, V.L., Roth, E., Ashani, Y., Silman,I. and Weiner, L.: Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase. Protein Science, 21,1138-1152 (2012)

- Silman I, Roth E, Paz A, Triquigneaux MM, Ehrenshaft M, Xu Y, Shnyrov VL, Sussman JL, Deterding LJ, Ashani Y, Mason RP, and Weiner L.: The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy. Chem. Biol. Interact, 203,63-66 (2013)

- Eliash,T., Barbon, A., Brustolon, M., Sheves, M., Bilkis, I. and Weiner,L.: Nitroxyl Radicals as a Tool for Studying Electron Transfer, Angewandte Chemie Intern. Edition,52 8689-8692 (2013)

- Moran Feller, Eyal Ben-Ari, Yael Diskin-Posner, Raanan Carmieli, Lev Weiner, and David Milstein.O2 Activation by Metal–Ligand Cooperation with IrI PNP Pincer Complexes. J. Amer. Chem. Soc.(on-line) April 1, 2015.