IN PRESS - Selected, just-accepted articles

Valentina Caputi, Ilaria Marsilio, Viviana Filpa, Silvia Cerantola, Genny Orso, Michela Bistoletti, Nicola Paccagnella, Sara De Martin, Monica Montopoli, Stefano Dall’Acqua, Francesca Crema, Iole-Maria Di Gangi, Francesca Galuppini, Isabella Lante, Sara Bogialli, Massimo Rugge, Patrizia Debetto, Cristina Giaroni and Maria Cecilia Giron

British Journal of Pharmacology

DOI: 10.1111/bph.13965

Impact factor: 5.773

First published: 30 August 2017

Background and Purpose. Gut microbiota is essential for the development of the gastrointestinal system, including the enteric nervous system (ENS). Perturbations of gut microbiota in early life have the potential to alter neurodevelopment leading to functional bowel disorders later in life. We examined the hypothesis that gut dysbiosis impairs the structural and functional integrity of the ENS, leading to gut dysmotility in juvenile mice.

Experimental Approach. To induce gut dysbiosis, broad-spectrum antibiotics were administered by gavage to juvenile (3weeks old) male C57Bl/6 mice for 14 days. Bile acid composition in the intestinal lumen was analysed by liquid chromatography-mass spectrometry. Changes in intestinal motility were evaluated by stool frequency, transit of a fluorescent-labelled marker and isometric muscle responses of ileal full-thickness preparations to receptor and non-receptor-mediated stimuli. Alterations in ENS integrity were assessed by immunohistochemistry and Western blot analysis.

Conclusions and Implications. Gut dysbiosis caused complex morpho-functional neuromuscular rearrangements, characterized by structural defects of the ENS and increased tachykininergic neurotransmission. Altogether, our findings support the beneficial role of enteric microbiota for ENS homeostasis instrumental in ensuring proper gut neuromuscular function during critical stages of development.

Paola Lanzafame, Siglinda Perathoner, Gabriele Centi*, Silvia Gross and Emiel J.M. Hensen

Journal: Catalysis Science & Technology

DOI: 10.1039/C7CY01067B

Impact factor: 5.773

Published on line 19.07.2017

This perspective discusses the general concepts that will guide future catalysis and related grand-challenges, based on "The European Roadmap on Science and Technology of Catalysis" prepared by the European Cluster on Catalysis. To adress the changing scenario in refinery and chemical production, and move to a low-carbon sustrainable future, the distinguishing elements of three grand-challenges for catalysis are discussed here: 1) catalysis to address the evolving energy and chemical scenario, 2) catalysis for a cleaner and sustainable future, and 3) addressing catalysis complexity, the latter being organized in three sub-topics: advanced design of novel catalysts, understanding catalysts from molecular to material scale, and expanding catalysis concepts


A. Politano, D. Campi, M. Cattelan, I. Ben Amara, S. Jaziri, A. Mazzotti, A. Barinov, B. Gürbulak, S. Duman, S. Agnoli, L. S. Caputi, G. Granozzi, and A. Cupolillo

Scientific Reports (IF= 5.228)

DOI : 10.1038/s41598-017-03186-x

We have investigated the electronic response of single crystals of indium selenide by means of angle-resolved photoemission spectroscopy, electron energy loss spectroscopy and density functional theory. The loss spectrum of indium selenide shows the direct free exciton at ~1.3 eV and several other peaks, which do not exhibit dispersion with the momentum. The joint analysis of the experimental band structure and the density of states indicates that spectral features in the loss function are strictly related to single-particle transitions. These excitations cannot be considered as fully coherent plasmons and they are damped even in the optical limit, i.e. for small momenta. The comparison of the calculated symmetry-projected density of states with electron energy loss spectra enables the assignment of the spectral features to transitions between specific electronic states. Furthermore, the effects of ambient gases on the band structure and on the loss function have been probed.

Vassalini, I., Borgese, L., Mariz, M., Polizzi, S., Aquilanti, G., Ghigna, P., Sartorel, A., Amendola, V. and Alessandri, I.

Chem. Int. Ed., 2017
doi: 10.1002/anie.201703387

Au–Fe nanoparticles synthesized by laser ablation in solution exhibit enhanced activity in the oxygen evolution reaction (see diagram). The results open exciting perspectives for using nanoalloys in catalysis and energy conversion.

C. Suchomski, D. J. Weber, P. Dolcet, A. Hofmann, P. Vöpel, J. Yue, M. Einert, M. Möller, S. Werner, S. Gross, I. Djerdj, T. Brezesinski and B. M. Smarsly

Journal of Material Chemistry A
DOI: 10.1039/c7ta02316b
I. F.: 8.262
First published online 24 April 2017

A cost-effective and tailored synthesis route for the preparation of cubic ZrO2 nanocrystals with high dispersibility was developed. The procedure is straightforward and produces uniform 2–3 nm particles of excellent yield when applying microwave dielectric heating as a “green” method. Furthermore, it can be applied to a wide range of batch sizes (from 0.5 to 20 g ZrO2), which makes it interesting for industrial applications, and also lends itself to the preparation of yttria-stabilized ZrO2 nanocrystals with varying doping levels. The work provides a blueprint for the fabrication of high-quality nanoparticles and structured materials thereof and is likely to trigger further research in the field of solution-processed metal oxides.


Sabrina Antonello, Tiziano Dainese, Fangfang Pan, Kari Rissanen, and Flavio Maran

Thiolate-protected metal clusters are materials of ever-growing importance in fundamental and applied research. Knowledge of their single-crystal X-ray structures has been instrumental to enable advanced molecular understanding of their intriguing properties. So far, however, a general, reliable, chemically clean approach to prepare single crystals suitable for accurate crystallographic analysis was missing. Here we show that single crystals of thiolate-protected clusters can be grown in large quantity and very high quality by electrocrystallization.

J. Am. Chem. Soc., Article ASAP 

Open Access

DOI: 10.1021/jacs.7b00568

Publication Date (Web): March 10, 2017

AlphaGalileo University of Jyväskylä (Finland)


Arianna Minelli, Paolo Dolcet, Stefano Diodati, Sandra Gardonio, Claudia Innocenti, Denis Badocco, Stefano Gialanella, Paolo Pastore, Luciano Pandolfo, Andrea Caneschi, Angela Trapananti Silvia Gross

Journal of Material Chemistry C

DOI: 10.1039/c6tc05636a

I. F.: 5.066

First published online 23 Feb 2017

A quick, easy and green water-based synthesis protocol involving coprecipitation of oxalates combined with hydrothermal treatment was demonstrated to be very effective in yielding and stabilising, at relatively low temperature (180°C) and in water, the crystallisation of nanostructured manganites. The subcritical hydrothermal approach was in fact shown to play a key role in stabilising phases which are generally achieved at much higher temperatures, and in harsher conditions, thus disclosing an exciting alternative for their synthesis. As a result of this mild wet chemistry approach, the compounds CuMnO2, ZnMn2O4 and ZnMnO3 were synthesised as nanocrystalline powders. Noticeably, the optimised route proved to be effective in stabilising the exotic polymorph cubic spinel ZnMnO3 as a pure compound. This is particularly notable, as very few records concerning this compound are available in literature. The manganites were characterised from a structural (XRPD and SAED, morphological (TEM and SEM) and compositional (XPS, ICP-MS, XAS and CHN analysis) point of view. Since these materials are particularly interesting for functional properties ascribed to their magnetic behaviour, SQUID was employed to study their magnetic properties, yielding a response that could indicate either ferrimagnetic or antiferromagnetic behaviour in CuMnO2 and ZnMnO3.

Ivan Guryanov,    Federico Polo,    Evgeniy Ubyvovk,    Evgenia Vlakh, Tatiana Tennikova,  Armin Tahmasbi Rad, Mu-Ping Nieh and FLAVIO MARAN

Chem. Sci., 2017, Accepted Manuscript

DOI: 10.1039/C6SC05187A  

First published online 02 Feb 2017

Poly(amino acid)-coated gold nanoparticles hold promises in biomedical applications, particularly because they combine unique physicochemical properties of the gold core, excellent biocompatibility, and easy functionalization of the poly(amino acid)-capping shell. Here we report a novel method of the preparation of robust hybrid core-shell nanosystems consisting of a Au144 cluster and a densely grafted polylysine layer. Linear polylysine chains were grown by direct N-carboxyanhydride (NCA) polymerization onto ligands capping the gold nanocluster. The density of the polylysine chains and the thickness of the polymer layer strongly depend on the amount and concentration of the NCA monomer and the initiator. The optical spectra of the so-obtained core-shell nanosystems show a strong surface plasmon resonance (SPR) like band at 531 nm. In fact, despite the gold-cluster size is maintained and the absence of interparticle aggregation, the polylysine-capped clusters behave as if they had a diameter nearly 4 times larger. To the best of our knowledge, this is the first observation of the growth of a fully developed, very stable SPR-like band for a gold nanocluster of such dimension. The robust polylysine protective shell makes the nanoparticles very stable under conditions of chemical etching, in the presence of glutathione, and at different pH values, without gold core deshielding or alteration of the SPR-like band. This polymerization method can be conceivably extended to prepare core-shell nanosystems based on other mono- or co-poly(amino acids). 

Simona Neri, Sergio Garcia Martin, Cristian Pezzato and Leonard J. Prins

DOI: 10.1021/jacs.6b12932

Published: January 2017

The activity of a gold nanoparticle-based catalyst can be reversibly up- and down-regulated by light. Light is used to switch a small molecule between cis- and trans-isomers, which inhibits the catalytic activity of the nanoparticles to different extent. The system is functional in aqueous buffer, which paves the way for integrating the system in biological networks.

Fabio Rizzo, Federico Polo, Gregorio Bottaro, Simona Fantacci, Sabrina Antonello, Lidia Armelao, Silvio Quici, and Flavio Maran

DOI: 10.1021/jacs.6b12247

Published: January 15, 2017

We describe the synthesis, computational analysis, photophysics, electrochemistry and electrochemiluminescence (ECL) of a series of compounds formed of two triphenylamines linked by a fluorene or spirobifluorene bridge. The
phenylamine moieties were modified at the para-position of the two external rings by electron-withdrawing or electron-donating substituents. These modifications allowed for fine-tuning of the photoluminescence (PL) and ECL emission from blue to green,
with an overall wavelength span of 73 (PL) and 67 (ECL) nm, respectively. For all compounds, we observed a very high PL quantum yield (79−89%) and formation of stable radical ions. The ECL properties were investigated by direct annihilation of the
electrogenerated radical anion and radical cation. The radical-ion annihilation process is very efficient and causes an intense greenish-blue ECL emission, easily observable even by naked eye, with quantum yield higher than the standard 9,10-
diphenylanthracene. The ECL spectra show one single band that almost matches the PL band. Because the energy of the annihilation reaction is higher than that required to form the singlet excited state, the S-route is considered the favored pathway followed by the ECL process in these
molecules. All these features point to this type of molecular system as promising for ECL applications. 

 Alice Antonello, Gerhard Jakob, Paolo Dolcet, Rebecca Momper, Maria Kokkinopoulou, Katharina Landfester, Rafael Muñoz-Espí, Silvia Gross*

Journal: Chemistry of Materials

IF: 9.407

DOI: 10.1021/acs.chemmater.6b03467

Accepted December 30 2016

Crystalline first row transition metal (Mn, Fe, Co, Ni, Cu and Zn) ferrites were prepared by an unprecedented synergetic combination of miniemulsion synthesis and solvothermal route, pursuing unconventional conditions in terms of space confinement, temperature and pressure. This synergy allowed for obtaining different crystalline ferrites at much lower temperature (i.e., 80 °C) than usually required and without any post-synthesis thermal treatment. X-ray diffraction (XRD) revealed that analogous ferrites synthesized by miniemulsion at ambient pressure or in bulk either at ambient pressure or under solvothermal conditions did not result in comparatively highly crystalline products. To follow the structural evolution at local level as a function of reaction time and depending on the synthesis conditions, X-ray absorption spectroscopy (XAS) was used to determine the cation distribution in these structures. Well-defined nanostructures were observed by transmission electron microscopy (TEM). Concerning their functional behavior, the synthesized ferrites presented superparamagnetism and were found to be active oxidation catalysts, as demonstrated for the oxidation of styrene, taken as a model reaction. Thanks to the magnetic properties, the ferrites can be easily recovered from the reaction medium, after the catalysis, by magnetic separation and reused for several cycles without losing activity.

 Marilena Di Valentin*, Marco Albertini, Maria Giulia Dal Farra, Enrico Zurlo, Laura Orian, Antonino Polimeno, Marina Gobbo and Donatella Carbonera

Journal: Chemistry-A European Journal IF: 5.771

DOI: 10.1002/chem.201603666

First published:9 November 2016

We report a pulsed electron paramagnetic resonance spectroscopic ruler for high-sensitive and accurate measurement of distances and distance distributions based on a novel spin labelling strategy. The ruler consists of a series of α-helical peptides, labeled at the N-terminal end with a porphyrin moiety, which can be excited to the triplet state, and with a nitroxide at various sequence positions, spanning distances in the range 1.8-8 nm. The new methodology has a high potential for measuring nanometer distances in proteins due to the distinctive properties of the porphyrin triplet state. Appropriate spin-labeling protocols can finally extend this novel strategy to any macromolecular system with a general impact in structural (bio)chemistry.