Part of Dr Thomas Scattolin's research activity focuses on the synthesis of organometallic compounds as potential anti-cancer agents. In particular, given the difficulty of predicting the cytotoxicity of an organometallic compound given the wide range of reactions it can undergo within a biological matrix, Dr Scattolin is trying to correlate the therapeutic response on ex vivo models (organoids extracted from ovarian carcinoma patients) of libraries of organometallic compounds with their steric and electronic characteristics. This extensive screening, aided by models linear or non-linear regression models, as well as machine learning approaches, should make it possible to define the structural characteristics that an organometallic compound must have for the treatment of a specific patient (customised chemical space).


Dr. Sergio Rampino – RTDb  (2/10/2023) - Polo: "Data"

Deeply rooted in theoretical and computational chemistry, the research activity of Dr. Sergio Rampino targets the modeling and understanding of chemical phenomena both from a structural and dynamic point of view. Involving the development of novel theoretical and computational techniques as well as their applications, his research embraces several topics of physical and inorganic chemistry including the quantum dynamics of elementary reactions, relativistic electronic structure, the analysis of chemical bonding, the stochastic modeling of macromolecules in solution, and the use of virtual-reality technology and artificial intelligence in chemistry.

Dr Migliore's research focuses on gaining understanding and the ability to control functional charge transfer and quantum dynamics in biomolecular complexes, spin systems, and other nanoscale systems, in contexts ranging from biocatalysis to protein-DNA interactions relevant to cancer research, from quantum control of molecular charge transfer to single-molecule conduction junctions, from (bio)molecules in quantum dynamics frameworks to solar energy harvesting. This interdisciplinary research is based on the use and development of theoretical-computational tools for multiscale analysis of systems, including an increasing focus on the context of quantum computing. My current research interests include:

- Charge-transfer and optical properties of molecules and nanocarbons
- Quantum dynamics and information transfer in chemical reactions
- Matter-energy interaction
- Light-driven biocatalysis
- Electronic properties of DNA and proteins
- Electronic structure calculations using Density Functional Theory.

Caterina is a departmental security management technician at the Department of Chemical Sciences.Her role is to implement and strengthen the safety management system.